Research Associate, Protein Engineering / Synthetic Biology

27. Juli 2022


The Institute of Molecular and Clinical Ophthalmology Basel (IOB) is seeking a highly motivated Research Associate.

IOB is a research institute combining basic and clinical research. Its mission is to drive innovations in understanding vision and its diseases and develop new therapies for vision loss. It is a place where your expertise will be valued, your abilities challenged, and your knowledge expanded.

In the role of Protein Engineering / Synthetic Biology Research Associate, you will bring your expertise in protein design and expression, to participate in developing and testing new therapies to restore vision.

A successful candidate will use first principles to predict/understand/control the impact of cell culture process parameters on membrane-bound recombinant protein function utilizing small-scale bioreactor models, and conduct mammalian cell tissue culture maintenance and DNA transfection / transduction. Cell cultures will be maintained and used for protein expression testing and production of designed proteins from recombinant DNA based vectors and other transduction systems.

Your responsibilities

  • Lead for development of new technologies in support of protein production, including transposon based stable cell expression capabilities and adherent cell lines for cell based assays
  • Ability to independently perform tissue culture assignments including protein production by transfection with recombinant DNA, and generation of stable CHO/HEK cell lines
  • Discuss scientific results and concepts internally in talks and progress reports
  • Present results to the external community at conferences and in publications
  • Maintain clear and accurate communication with supervisor and other team members


  • PhD or equivalent experience in Molecular Biology, Biochemistry, Structural Biology, Cell Biology or related discipline in Life Sciences
  • Minimum 3 years-experience in, at least, two of the following fields: (1) directed evolution; (2) library generation and microplate readers; (3) molecular biology; and/or (4) microscopy
  • Enthusiasm to establish and optimize new protocols and techniques at the bench
  • The candidate should be highly organized, precise, detail-oriented and computer skilled
  • Proficient with sterile laboratory maintenance, and familiar with BSL1-2 requirements
  • Years of experience and track record in protein design

We offer

  • Highly competitive conditions in a dynamic and international research community in Basel
  • IOB is an equal-opportunity employer with family-friendly work policies

Application / Contact

Interested candidates should submit their application online via the recruitment platform. Please include a personal statement, your Curriculum Vitae and indicate the job title on the subject line.

For further information, please visit our website, contact Dr. Guilherme Testa-Silva ( or reply to the confirmation mail that you will receive after applying.

IOB – Institute of Molecular and Clinical Ophthalmology Basel
Sandro Crameri
Head of Human Resources
: +41 79 511 26 54

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